Abstract Objective: The aim of our study was to evaluate the expression of MMP-2 and MMP-9 as a prognostic factor in patients diagnosed with Hodgkin Lymphoma (HL). Methods: In the present study, 45 paraffin biopsies from patients up to 19 years old diagnosed with HL were used in two referral hospitals in the state of Pernambuco, Brazil. Risk groups were classified into favorable and unfavorable, according to Ann Arbor. The expression of matrix metalloproteinases 2 and 9 and their inhibitors was performed by immunohistochemistry (IHC). Data were analyzed using the GraphPad Prism 5 program. Results: MMP-2 intensity pattern was stronger (> 10% of the total field) in patients with stage III/ IV and B symptoms. MMP-2 showed an association with the risk group (p = 0.0388). That is, the stronger the MMP-2 marking, the greater the unfavorable risk. However, for MMP-9 there was no difference in the stronger intensity pattern in relation to stages I/II and III/IV, only in the presence of B symptoms. MMP-9 showed an association with B Symptoms (p = 0.0411). Therefore, patients with B symptoms have higher MMP-9 expression. Conclusion: Our results suggest that MMP-2 expression is associated with HL progression. While MMP-9 expression is related to the clinical worsening of these patients. However, further studies are needed to evaluate the exact role of these proteins in hematologic malignancies.

Resumo A reutilização dos resíduos de construção civil (RCC) vem sendo adotada como uma maneira de reduzir os impactos causados pela geração e disposição inadequada desse material em todo o mundo. A estabilização de solos com cimento é uma prática comum para viabilizar a utilização desse material em diversas obras, entretanto, dependendo do tipo de solo, são necessárias grandes quantidades de cimento, tornando a técnica inviável. O uso do RCC no processo de estabilização do solo pode ser uma alternativa para reduzir o teor de cimento utilizado e melhorar a resistência da mistura. O objetivo desse trabalho foi investigar o uso do RCC em substituição parcial de um solo argiloso laterítico em misturas de solo-cimento. Além do solo natural, foi utilizada uma mistura de solo e RCC (S-RCC) usando proporções com 50% para cada material. Os teores de cimento avaliados foram 0, 4, 6 e 8% e os períodos de cura variavam de 7 a 28 dias. Os resultados indicaram que a mistura S-RCC com cimento apresenta resistência superior ao solo-cimento. Isto confirma que o uso de RCC reduz os teores de cimento necessários à estabilização de um solo argiloso e se apresenta como uma alternativa mais ambientalmente apropriada para a destinação deste material.

Abstract The reuse of construction waste (CW) has been increasingly adopted as a way to reduce the environmental impact from inadequate disposal of this material worldwide. The stabilization of soils with cement is a common practice, enabling the use of this material in a variety of projects. However, depending on the type of soil, frequently large quantities of cement are needed, making the technique impracticable. The use of CW in the soil stabilization process may be an alternative for reducing the amount of cement and improving the strength of the mixture. The objective of this work was to investigate the use of CW to partially replace a lateritic clay soil in soil-cement mixtures. Besides the natural soil (S), a mixture of soil and CW (S-CW) was used with proportions of 50% of each. The cement content levels evaluated were 0%, 4%, 6% and 8% and the curing periods varied from 7 to 28 days. The results showed superior strength values for the S-CW compared to the soil-cement. This confirms that the use of CW reduces the percentage of cement necessary for the stabilization of a clayey soil and presents an alternative, more environmentally appropriate destination for this material.